Furthermore, the primary requirement for any colon targeted formulation is to resist the drug degradation at gastric pH and successfully deliver it to colon. After formulation of CLX NLCs, coating performed with gastric resistant colon specific polymer Eudragit S100 (EUD S100) to ensure the protection of CLX in harsh gastric environment and site-specific delivery of CLX-loaded NLC in the colon.
The targeted drug delivery is dependent on the identification and exploitation of a attribute that is specific to the target organ1, 2. The colon targeted drug delivery is beneficial for the localized treatment of several colonic diseases mainly inflammatory bowel diseases (IBD), irritable bowel syndrome and colonic cancer.
Abstract Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn's disease, amoebiosis, colonic cancer, local.
New systems and technologies have been developed for colon targeting and to overcome pervious method’s limitations. Colon targeting holds a great potential and still need more innovative work. This review article discusses introduction of colon, need and approaches of colonic drug delivery, factor effecting colonic transition, colonic diseases and the novel and emerging technologies for.
Delivery of a drug to a specific organ or tissue i.e. spatial placement and controlling the rate of drug delivery to the specific sites i.e. temporal delivery are the two main aspects of the drug delivery systems1. Now a day the colon has recently become accepted as an increasingly important site for drug delivery. Colon specific diseases are often.
Hence, the current drug delivery system to the colon is based on one-size-fits-all. Fails to effectively deliver the drugs locally to the colon for colonic diseases and delivery of therapeutic proteins and peptides for systemic absorption from the colon.
Stimuli sensitive polysaccharide based hydrogels as colon targeted drug delivery vehicles: a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University, Turitea campus, Palmerston North, New Zealand.
This review mainly focused on various site specific oral drug delivery systems and detailing about Buccal Patches, Medicated chewing gums, Colon targeted drug delivery system, Osmotic tablets, Pulsincap system, Egalet technology etc. Keywords.